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CAS NO.112809-51-5
A(1-10)Metric TonA(20-50)Metric Ton
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Quick Detail:
Producct name: Letrozol Femara
CAS No: 112809-51-5
Molecular formula: C17H11N5
Molecular weight: 285.3
Appearance: White power
Usage: Letrozoles has a 2-4 day half-life, and it needs to be taken for up to 60 days to get a steady blood plasma evel, using Letrozolesat such a low dose does happen to make it a very good economic choice compared with other aromatase inhibitors.
Description:
Letrozole Femara is approved by the United States Food and Drug Administration (FDA) for the treatment of local or metastatic breast cancer that is hormone receptor positive or has an unknown receptor status in postmenopausal women.
Femara is used for the treatment of post-menopause breast cancer.
Femara is a powerful Aromatase Inhibitor that was developed to fight breast cancer. For athletes and bodybuilders, it is a drug used to combat the estrogenic side effects of anabolic steroids water-retention, acne and gynocomastia. It will also raise testosterone levels because of the lowered estrogen in the body. Side effects from include a lowered sex drive and continuous use can lead to lowered lipid function and an impaired immune system.
Letrozol Femara Recipes:
200ml @ 5 mg/ml
1 gram of powder
1 beaker suitable for holding the volume of liquids
19.9 ml of PEG 300
179.1 ml of 190 Proof Grain Alcohol
Letrozol Femara COA:
Product name |
Letrozol Femara powder |
|
Items |
Specifications |
Results |
Appearance |
White or off-white powder |
White powder |
Identification |
FT-IR、HPLC、NMR、Mass |
Confirm |
Water |
≤0.3% |
0.20% |
Melting point |
180℃ - 184℃ |
182.1℃ |
Residue on ignition |
≤0.1% |
0.06% |
Heavy metals |
≤10 ppm |
Confirm |
Related substances |
||
4, 4'- (1H-1,3,4-triazol-1-ylmetyhlene) dibenzonitrile |
≤0.3% |
Confirm |
4, 4'4"- Methylidenen-trisbenzonitrile |
≤0.2% |
Confirm |
Any other single impurity |
≤0.1% |
Confirm |
Total impurities |
≤0.3% |
0.1% |
Residual Solvent (Meets the requirements of ICH) |
||
Acetone |
≤5000 ppm |
480 pp0m |
Bulk density (tapped) |
0.3 g/ml - 0.7 g/ml |
0.37 g/ml |
Assay |
98.0% - 102.0% |
99.9% |
Effects:
In one male test subject Letrozole was able to reduce estrogen levels to undetectable levels Letrozole is able to raise in male subjects.
Letrozole has also been shown to delay the fusing of the growth plates in mice. When used in combination with hormone, letrozole has been shown effective in one adolescent boy with a short stature; Letrozole has also been used to treat endometriosis a C17 α-alkylation which allows the hormone to survive first-pass liver metabolism when ingested. It is because of this that is also sold in tablet form.
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