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CAS NO.140703-51-1
A(1-10)Metric TonA(20-50)Metric Ton
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Desctiprion:
Product Name: Hexarelin
Synonyms: Examorelin
CAS: 140703-51-1
MF: C47H58N12O6
MW: 887.04
Purity (HPLC): 98.0%
Appearance: White powder
Single Impurity (HPLC): 0.5%max
Amino Acid Composition: ±10% of theoretical
Peptide Content (N%): ≥80.0%
Water Content(Karl Fischer): ≤8.0%
Acetate Content(HPIC): ≤10.0%
Description:
Hexarelin is a six-amino acid peptide. Studies have shown that hexarelin is actually more
effective and longer lasting than growth hormone releasing hormone (GHRH). It is also known that
GHRP-6 has a synergistic effect with GHRH, causing a far greater release than either of these
substances alone. By combining GHRP-6 with Hexarelin, a more potent GH releasing peptide
combination is created than ever heard of. The potential clinical usefulness of these GH releasing
hexapeptides is also reinforced by observations that long-term administration produces
elevations in circulating IGF-1 concentrations. Long term treatment with GHRP-6 similarly has
been shown to elevate serum IGF-1 as well as IGF-binding protein-3 concentrations and promote
linear growth.
Hexarelin comes in a freeze dried powder just like the other GHRP peptides and storage should
be done in a cool dry place until reconstituted and placed in a refrigerator. Bacteriostatic water is
used to reconstitute the powder and an insulin syringe is the preferred method for administering
subcutaneous injections of hexarelin. Users will notice 200mcgs is the saturation dose for
hexarelin and over a few weeks of use total desensitization may begin to take place. Also, the
occasional flare up of the pituitary has been noted when dosing far beyond saturation doses.
Desensitization can be cleared easily by taking a break from hexerlin usage for a few days to a
few weeks. This GHRP is the strongest, and because of the desensitization factor, I believe the
optimal way to use this peptide would be to blend it at low doses with other GHRP's like GHRP2,
GHRP6 or iPamorelin.
Application:
Hexarelin is an appetite-regulating factor secreted from peripheral organs that is involved in
regulation of energy homoeostasis via binding to the receptor resulting in the secretion of by the
pituitary gland.The pathway activated by binding of Hexarelin to the secretagogue receptor,
GHSR1a, regulates the activation of the downstream mitogen-activated protein kinase, Akt, nitric
oxide synthase, and AMPK cascades in different cellular systems.
One of the important features of GHSR1a displays constitutive activity possessing basal activity
in the absence of an agonist, resulting in a high degree of receptor internalization as well as of
signaling activity.Inverse agonists for the Hexarelin receptor could be particularly interesting for
the treatment of obesity.This activity seems to provide a tonic signal required for the development
of normal height, probably through an effect on the GH axis
Benefits:
Interestingly, the most amazing finding with hexarelin was its ability to act on cardiac receptors
separate from the GH releasing properties. The peptide can directly aid in cardio protective left
ventricular pressure issues, as well as, help healing scar tissue on the heart. Studies on lean and
obese lab rats concluded that while lean rats were able to take advantage of the GH plasma
increase better than the obese rats (the healthier the rat the more hexarelin effectively produced
and utilized GH), obese rats did not see the same advantage. Separate from the studies that
monitored GH, both lean and obese rats both received all of the cardio protective properties of
hexarelin.
The functionality:
Hexarelin (Hexarelin Acetate) is chemically designed as L-Histidyl-2-methyl-D-tryptophyl-L-alanyl-
L-tryptophyl-D-phenylalanyl-L-lysinamide. Hexarelin (Hexarelin Acetate) is a potent GHRP-6
analog, whose structure (His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2) creates a greater stability
than GHRP-6 due to a substituted (2 Me)Trp. Hexarelin has a half-life of about 70 min, longer than
that of GHRP-6. Replacement of the naturally occurring L-amino acids for the D-configuration
results in these longer half-lives.
Secretion:
Hexarelin has shown that it is highly stimulated at 30 minutes after being induced by rapid and
sustained GH secretion. The pituitary gland produces GH in the brain, in children this hormone
helps them to grow and in adults it helps to maintain muscle and burn fat. In one sixteen-week
study, it has been shown that GH levels return to normal after stopping use after four weeks.
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