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CAS NO.159752-10-0
A(1-10)Metric TonA(20-50)Metric Ton
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Quick Detail:
| Product Name |
Ibutamoren,MK-677 |
| Alias |
MK-0677,L-163191,Nutrobal |
| CAS |
159752-10-0 |
| MF |
C27H36N4O5S.CH4O3S |
| MW |
624.776 |
| Purity |
99% |
| Appearance |
White Powder |
| Grade |
Pharmaceutical Grade |
| Product Categories |
SARMs(Selective androgen receptor modulator) |
MK-677 Description:
MK-677 is an oral HGH SECRETAGOGUE that provides higher amplitude to the dozen or more hgh pulses put out by the pituitary gland over the 25 hour half-life of the drug. Once daily use before bed at a dose of 25mg provides all of the benefits of elevated HGH and Igf1 such as deeper sleep with more vivid dreams, improved skin, faster hair and nail growth, fat loss, lean muscle gain, increased strength, greater nitrogen retention the the skeletal muscles, greater protein synthesis, etc.
Nutrobal (Mk-677) is an orally administrated growth hormone secretagogue originally developed by Reverse Pharmacology.A secretagogue is the term for a substance that chemically signals for the pituitary gland to secrete growth hormone. In other words, Nutrobal could be compared to peptides like GHRP-6 or Ipamorelin, only it doesn't require any injections nor does it have any side effects like GHRP-6. This GHS (Growth Hormone Secretagogue) was developed in an aim to combat such conditions as muscle wasting, obesity and osteoporosis. It was also targeted towards treatment of elderly hip fracture patients, so there are a myriad of studies done on safety.
MK-677 Application:
Growth hormones pulse intensity can be increased through 4 possible mechanisms:
Increasing GHRH (growth hormones releasing hormone) release.
Amplifying GHRH signaling in somatotrophs of the anterior pituitary gland.
Reducing somatostatin release (somatostatin turns off GH release).
Inhibiting of somatostatin receptor signaling.
Nutrobal (Mk-677) was found to work through all four of these mechanisms. After ingestion, Growth Hormones (GH) was shown to increase dose dependently, at doses starting at 5 milligrams (mgs) a day.
Produced by Reverse Pharmacology, MK 677 (Nutrobal) is an orally administered growth hormone secretagogue that is designed to stimulate the pituitary gland to release growth hormones. In case you're wondering, "secretagogue" is basically a natural substance that causes another substance to be secreted, such as gastrin.
MK 677 (Nutrobal) was originally formulated to keep health problems like osteoporosis, obesity and muscle wasting, but has been seen to promote an increase in lean body mass as well as a boost in IGF-1 serum concentration during clinical runs.
MK-677 COA:
| Product name |
MK-677 |
|||
| Batch No. | SYN20160803 | Quantity |
1.3KG |
|
| Manu. date | 2016-08-03 | Retest date |
2018-08-02 |
|
| CAS# | 159752-10-0 | Ref. standard |
In-house standard |
|
| Items | Specifications |
Results |
||
| Appearance | Light yellow powder |
Conforms |
||
| Identification | IR, HPLC – Should comply |
Conforms |
||
| LS-MS | Confirms to MW |
PASS |
||
| melting point | 158-160℃ |
156-158℃ |
||
| Assay (HPLC) | ≥99.0 % |
99.54% |
||
| Specific Rotation | -15.71 |
-15.9 |
||
|
Conclusion: Complies with in-house standard. |
||||
MK-677 Benefits:
Increased Fat Oxidation (fat loss).
Increased Muscle gains (lean mass).
Tightening up loose skin.
Healing old injuries.
Healing Bones, Tendons and Ligaments.
In a study on it's effects on catabolic states, a once daily oral dose of 25mgs was given to healthy young mensubjected to short-term diet-induced nitrogen wasting.
After 7 days of this dose, the subjects showed a sustained increase in serum concentration of
IGF-1 and Hormone; in addition, the nitrogen wasting was reversed, showing great potential for treatment of conditions involving muscle wasting.
A study done for the treatment of osteoporosis and bone mineral density showed some increase
in bone density, so there is a true impact on bone mineral density. This can help with injury
recovery during your cycle.
MK-677 Usage:
MK-677 is a medicine which acts as a potent, orally active growth hormones secretagogue,
mimicking the GH stimulating action of the endogenous hormone ghrelin. It is currently under
development as a potential treatment for reduced levels of these hormones, such as in growth
hormones deficient children or elderly adults, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly. It also alters metabolism of body fat and so may have application in the treatment of obesity.
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