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CAS NO.65-19-0
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Quick Details
| Product Name |
Yohimbine Hydrochloride |
| Synonyms |
17-hydroxyyohimban-16-carboxylic acid methyl ester hydrochloride; 17a-hydroxyyohimban-16a-carboxylic acid methyl ester hydrochloride; Yohimbe hcl;Yohimbine hcl |
| CAS |
65-19-0 |
| EINECS |
200-600-4 |
| MF |
C21H27ClN2O3 |
| MW |
390.9 |
| Molecular Structure | |
| Grade |
Pharmaceutical grade |
| Standard |
Enterprise Standard |
| Assay |
99% |
| Appearance |
White to slightly yellow powder |
| Solubility |
H2O: 10 mg/mL |
| Usage |
Indole alkaloid with α2-adrenergic blocking activity. Mydriatic. Used in the treatment of neurological disorders. |
What is Yohimbine hydrochloride
Derived from wild African plants yohimbine (Corynante Yohimbe) dry bark or west African plant rubiaceae keNan Tree bark extract.Pharmacological efficacy to increase muscular tension, urine suppression effect without injury;Accelerate the body energy metabolism, increase energy supply.Clinical single agent used to treat male impotence and hypogonadism.Mechanism for can selectively block presynaptic alpha 2 receptor, promote the release of norepinephrine, the cavernous nerve endings release more noradrenaline, reduce penile venous reflux, conducive to congestion erection, and can increase fluid secretion.A small amount of applications, can make the perineum swelling, stimulate the spinal cord erection center and make the sexual function hyperfunction.
Increase muscular tension or urinary function no damage sex; Accelerate human body energy metabolism, increase energy supply.
Yohimbine has been shown in human studies to be effective in the treatment of male impotence. Yohimbine has been shown to be effective in the treatment of orgasmic dysfunction in men. Yohimbine has also been used to treat hypoactive sexual desire disorder (reduced libido) in women.
Yohimbine has been used to facilitate recall of traumatic memories in the treatment of post traumatic stress disorder (PTSD). Use of yohimbine outside therapeutic settings may not be appropriate for persons suffering from PTSD. In pharmacology, yohimbine is used as a probe for α 2-adrenoceptor. In veterinary medicine, yohimbine is used to reverse anesthesia from the drug xylazine in small and large animals
Applications
1. Fat Loss
Yohimbe and other alkaloids in the bark extract are said to block specific receptors that actually inhibit fat loss. A three-week study in 1991 observed 20 obese females on 1,000-calorie diets. They were given 20 mg of yohimbe each day and lost three pounds more than the group receiving placebos. Not a drastic weight loss, but enough to give experts hope that yohimbe can help with weight loss. Other studies have found that yohimbe increases the amount of non-esterified fatty acids, a result of fat breaking down. More research is needed. Most other studies in the field are done using the drug yohimbine. Extracted chemicals are not the same as yohimbe bark. Studies with yohimbine are expected to give different results than studies that used the raw plant.
2. Appetite Suppressant
Yohimbine also has another advantage for dieters--appetite suppression. Studies have shown that supplementation with yohimbine reduces overall calorie intake by neutralizing feelings of hunger.
Interestingly, one study found that yohimbine reduced carbohydrate and fat intake, but not protein intake. This assists in appetite suppression because protein increases feelings of fullness. Your body also burns more calories digesting protein than it does digesting carbohydrates or fat.
3. Sexual Health
Yohimbine HCl has shown to rapidly increase the Libido of both men and women and its properties as an aphrodisiac are well known throughout the scientific world. Yohimbine HCl increases the sex drive of men and is even used to treat hypoactive sexual desire disorder (under active libido) in women.
Its most pronounced sexual effect appears to be in its treatment of Erectile Dysfunction in men and has shown to even increase penile girth (the width of the male penis). Through its effect on minor corpus cavernosum smooth muscle relaxation, the vasodilatation caused increases blood flow to the penis exponentially. Continual use of Yohimbine HCl is required to achieve these results as it cannot be achieved through casual or one time usage.
Yohimbine hydrochloride Dosage
Clinically, doses of approximately 2mg per kilogram per day have been shown to be effective is reducing body fat for both men and women. This type of dosing should also result few side effects for the user.
The half life of yohimbine is only about one to two hours, however because the half life of the metabolite 11-hydroxy-yohimbine is six to eight hours a user should only have to take doses of the supplement two or three times per day to see the full effects.
It is recommended that yohimbine be taken on an empty stomach as if it was to be taken with meals this may reduce it's lipolytic effects.
COA
| ANALYSIS | SPECIFICATION | RESULTS |
| Appearance | White fine powder | Complies |
| Odor | Characteristic | Complies |
| Assay (HPLC) On dry basis | Yohimbine HCL≥98.0% | 99. 3% |
| Sieve analysis | NLT 100% pass 80 mesh | Complies |
| Melting point | 285-290°C | 288.2ºC |
| Boiling point | 542.979°C at 760 mmHg | Complies |
| Flash point | 282.184°C | Complies |
| Vapour Pressur | 0mmHg at 25°C | Complies |
| Specific Rotation | +100º to +105º | +103.80º |
| Solubility | Slightly soluble in Water/Alcohol | Complies |
| Loss on Drying | ≤1% | 0.7% |
| Residue on Ignition | ≤1% | 0.87% |
| Heavy Metal | <15ppm | <10ppm |
| As | <2.0ppm | <1ppm |
| Pb | <1.0ppm | <0.4ppm |
| Cd | <1.0ppm | 0ppm |
| Hg | <0.1ppm | 0ppm |
| Residual Solvents | Eur.Pharm. | Complies |
| Microbiology | ||
| Total Plate Count | <1000cfu/g | Complies |
| Yeast & Moulds | <100cfu/g | Complies |
| E.Coli | Negative | Complies |
| Salmonella | Negative | Complies |
| S.aureus | Negative | Complies |
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