Doublewin Biological Technology Co., Ltd.(expird)
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Country: 
China (Mainland)
Business Type:Lab/Research institutions
CAS NO.164656-23-9
Our Competitive advantages:
1. Rich experience.
We specialize in this field for many years, our steroids and hormones exported to all over the world and established long friendly relations of cooperation with them.
2. Great quality, purity and favorable.
Good quality is one of our biggest secret to success; you can get the best quality and service from us.
3. Safest and fastest delivery.
We have adequate stock so that we can deliver the products within 24 hours as soon as receiving the payment. Fast and discreet shipment will be arranged to pass Customs.
4. Good package.
Unique ways to ship 10g to100kg powders to your destination. We offer melting powder into liquid service and ship the liquid in special bottles.
5. Great after-sales service.
Any questions or problems after receiving the product, please feel free to contact us. Problems would be solved immediately.
General Comments:
We have professional team for package and shipment. Unique ways to ship 10g to100kg powders at one time to your country. Our shipments are by DHL, TNT, FEDEX, HKEMS, UPS, etc for 25kg, between 25kg~200kg by air, over 200kg by sea. Fast and secure shipment could be arranged for customs pass Guaranteed.
Our company has independent import and export authority, also has the certificate of importing and exporting pharmaceutical materials. At the same time we are developed manufacturers with mass stock.
Just try a small order to start our cooperation, we will NOT make you down !
Any products interested pls let me know I will give info.in details.
Dutasteride Description:
Dutasteride, sold under the brand name Avodart among others, is a medication used to treat benign prostatic hyperplasia (enlarged prostate) and androgenetic alopecia (pattern hair loss).
Dutasteride is occasionally used for treating benign prostatic hyperplasia (BPH); colloquially known as an "enlarged prostate". It is approved by the Food and Drug Administration (FDA) in the U.S. for this indication.
Dutasteride (Avodart)
English Synonyms: DUTASTERIDE;GG-745, GI-198745,Duagen,Avodart;GI 198745
CAS NO.: 164656-23-9
Assay: 99%
Molecular Formula:C27H30F6N2O2
Molecular Weight:528.53
Packing:1kg/tin/foil bag
Standard: Enterprise
Appearance: White or almost white crystalline powder
Usage: Prostate enlargement, male pattern hair loss, seborrheic alopecia, hereditary hair loss
Payments: T/T,West Union,Money Gram,etc
Qualitification: ISO 9001, KOSHER,UKAS
Delivery time: send within 24 hours after we check your payments,usually reach U within a week
Min order: 10g
Price: change according to the market fluctuations, pls ask the price before purchase!
Top quality products with the most competitive rate. Free samples are available.
Well disguised packing.
Flexible and untraceable payment terms
Exclusive customer service and 24/7 online timely and helpful After-sale service.
Usage:
Dutasteride is approved for the treatment of male androgenetic alopecia in South Korea at a dosage of 0.5 mg per day.
It has been found in several studies to improve hair growth in men more rapidly and to a greater extent than 2.5 mg/day finasteride.
Dutasteride has also been used off-label in the treatment of female pattern hair loss.
Excessive hair growth
Although no reports specific to dutasteride currently exist, 5α-reductase inhibitors like finasteride have been found to be effective in the treatment of hirsutism (excessive facial and/or body hair growth) in women. In a study of 89 women with hyperandrogenism due to persistent adrenarche syndrome, finasteride produced a 93% reduction in facial hirsutism and a 73% reduction in bodily hirsutism after 2 years of treatment.Other studies using finasteride for hirsutism have also found it to be clearly effective. Dutasteride may be more effective than finasteride for this indication due to the fact that its inhibition of the 5α-reductase enzyme is comparatively more complete.
Prostate cancer
The FDA has added a warning to dutasteride about an increased risk of high-grade prostate cancer. While the potential for positive, negative or neutral changes to the potential risk of developing prostate cancer with dutasteride has not been established, evidence has suggested it may temporarily reduce the growth and prevalence of benign prostate tumors, but could also mask the early detection of prostate cancer. The primary area for concern is for patients who may develop prostate cancer whilst taking dutasteride for benign prostatic hyperplasia, which in turn could delay diagnosis and early treatment of the prostate cancer, thereby potentially increasing the risk of these patients developing high-grade prostate cancer.
Contraindications
Children, women who are or who may become pregnant, and people with known significant hypersensitivity (e.g., serious skin reactions, angioedema) to dutasteride or finasteride should not take dutasteride. Exposure to dutasteride and other 5α-reductase inhibitors during pregnancy can cause birth defects. Since these medications are readily absorbed through the skin, women who are or may become pregnant should not handle them and if they come into contact with leaking capsules, the contact area should be washed immediately in soapy water. People taking dutasteride should not donate blood and, due to its long half-life, should also not donate blood for at least 6 months after the cessation of treatment.
Pharmacology
Dutasteride belongs to a class of drugs called 5α-reductase inhibitors, which block the action of the 5α-reductase enzymes that convert testosterone into DHT. It is an irreversible inhibitor of all three isoforms of 5α-reductase, types I, II, and III.This is in contrast to finasteride, which is similarly an irreversible inhibitor of 5α-reductase but only inhibits the type II and III isoenzymes.As a result of this difference, dutasteride is able to achieve a reduction in circulating DHT levels of as much as 98%, whereas finasteride is only able to achieve a reduction of 65 to 70%. In spite of the differential reduction in circulating DHT levels, the two drugs decrease levels of DHT to a similar extent of approximately 85 to 90% in the prostate gland,where the type II isoform of 5α-reductase predominates.
In addition to DHT, dutasteride prevents the 5α-reductase-mediated formation of neurosteroids such as allopregnanolone, THDOC, and 3α-androstanediol (see also neurosteroidogenesis inhibitor).These neurosteroids are potent positive allosteric modulators of the GABAA receptor and have been found to possess antidepressant, anxiolytic, and pro-sexual effects in animal research.For this reason, prevention of neurosteroid formation may be involved in the sexual dysfunction and depression that has been associated with 5α-reductase inhibitors like dutasteride.
Pharmacokinetics
Dutasteride has an extremely long terminal half-life of four or five weeks.For this reason, it takes months for dutasteride to be eliminated from the body after discontinuation. In contrast to dutasteride, the terminal half-life of finasteride is short, at only 6 to 8 hours.