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CAS NO.4759-48-2
A(10-50)Metric Ton
Quality
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2. All purity> 99%.
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6. Can provide NMR, HPLC and COA
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Product name | Isotretinoin (13-cis Vitamin A acid) | ||
CAS No. | 4759-48-2 | Packing | 100G/25KG |
Date of manufacturing | 2th, July, 2016 | Shelf life | 1th, July, 2018 |
Standard | USP34 | ||
ITEMS | SPECIFICATION | RESULTS | |
Appearance | Yellow or orange crystalline powder | Complies | |
Identification | Complies | Complies | |
Loss on drying | Not more than 0.5% | 0.05% | |
Residue on ignition | Not more than 0.1% | 0.02% | |
Heavy metals | Not more than 0.002% | <0.002 | |
Tretinoin | Not more than 1.0% | 0.1% | |
Assay | 98%~102.0% | 99.8% | |
Conclusion | Qualified |
Isotretinoin ,also known as 13-cis-retinoic acid, is an oral pharmaceutical drug primarily used to treat severe nodular acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body. Its isomer, tretinoin, is also an acne drug.
Isotretinoin is primarily used as a treatment for severe acne. The most common adverse effects are a transient worsening of acne (lasting 2-3 weeks), dry lips (cheilitis), dry and fragile skin, and anincreased susceptibility to sunburn. Uncommon and rare side effects include muscle aches and pains , and headaches. Isotretinoin is known to cause birth defects due to in utero exposure because of the molecule's close resemblance to retinoic acid, a natural vitamin A derivative which controls normal embryonic development.
It belongs to a class of drugs known as retinoids. It works by decreasing facial oil (sebum) production. High amounts of sebum can lead to severe acne. If left untreated, severe acne may cause permanent scarring.
Other uses: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.