Keywords

• DSIP
• Delta Sleep inducing Peptide
• CAS 62568-57-4

Quick Details

• ProName: Lab supply Analgesic Effect Delta Slee...
• CasNo: 62568-57-4
• Molecular Formula: C35H48N10O15
• Appearance: White Crytalline Powder
• Application: Muscle building peptides, human growth...
• DeliveryTime: Within 24 hours after receiving paymen...
• PackAge: designed disguised packing ways, 100% ...
• Port: Shenzhen
• ProductionCapacity: 100 Kilogram/Week
• Purity: 99%
• Storage: Store in a cool and dry place, keep dr...
• Transportation: HKEMS, DHL, TNT, UPS, FEDEX, EMS, Chin...
• LimitNum: 1 Gram

Superiority

1. We have experience in exporting steroids, as you know, EU places much emphasis on them, and you must find a experienced partner who will assure you;

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3. Package: Professional packing with professional materials

4. Delivery: We have products in stock, and we will deliver them soon when your PO arrived.

Meanwhile we will give you the tracking number in order to make you know the exact location of the products. We will keep track of the product until they arrive you; We choose the best courier service for you, and with the delivery around 4-7 working days.

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Details

DSIP Function

Many roles for DSIP have been suggested following research carried out using peptide analogues with a greater molecular stability and through measuring DSIP-like immunological (DSIP-LI) response by injecting DSIP antiserum and antibodies

Roles in endocrine regulation

Decreases basal corticotropin level and blocks its release.
Stimulates release of luteinizing hormone (LH).
Stimulates release of somatoliberin and somatotrophin secretion and inhibits somatostatin secretion.

Structure and Interactions

DSIP is an amphiphilic peptide of molecular weight 850 daltons with the amino acid motif:N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C

It has been found in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids.[5] In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). It is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon.

In vitro it has been found to have a low molecular stability with a half life of only 15 minutes due to the action of a specific aminopeptidase-like enzyme.It has been suggested that in the body it complexes with carrier proteins to prevent degradation, or exists as a component of a large precursor molecule,but as yet no structure or gene has been found for this precursor.

Evidence supports the current belief that it is regulated by glucocorticoids.

Gimble et al. suggest that DSIP interacts with components of the MAPK cascade and is homologous to glucocorticoid-induced leucine zipper (GILZ).GILZ can be induced by Dexamethasone. It prevents Raf-1 activation, which inhibits phosphorylation and activation of ERK.

Roles in Disease and Medicine

Anticarcinogenic
Analgesic effect
Geroprotective effects