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The Benefits of CJC 1295 with DAC
Most benefits associated with the use of CJC 1295 with DAC have been associated with muscle development. It is able to do so because of its ability to increase muscle tissue growth and improve protein synthesis. Hence, most of its users include fitness buffs, athletes and body builders. Clinical trials and anecdotal evidence have shown that I can considerably improve one's physical performance. It is also thought to increase muscle strength, promote overall body mass whilst increase muscle gain. Benefits of CJC 1295 with DAC has also been associated with cell growth stimulation, skin, internal organ mass and immunity improvement as well as improved sleep. Anecdotal evidence has shown that it promotes faster recovery from muscle injuries and improvement of mental well-being.
Application
CJC-1295 is an injectable peptide used to increase GH production. This peptide is a hormone releasing hormone (GHRH) mimetic, or analog. That is to say, it works in the same way as GHRH, and may be referred to as being a GHRH.
The principal use of CJC-1295 is to provide increased GH levels, which also results in increased IGF-1 levels. An increase in these levels can aid fat loss and in some instances can aid muscle gain as well.
Generally, a product in the GHRH category, including CJC-1295, is chosen as an alternate to using GH, and only rarely is combined with GH.
Description
CJC-1295 is a derivative of human GH-releasing factor1-29(HGRF1-29). HGRF1-29 is a naturally occurring peptide that is actually a truncated form of a larger peptide that binds to the growth hormone secretagogue receptor (GHS-R) and causes the release of growth hormone. CJC-1295 has four amino acids substituted in its chain that result in strong binding to serum albumin and prolong its half-life in the body.
Because of the way CJC-1295 is engineered its half life has been extended from ~7 minutes to greater than 7 days!. This is convenient as it means the product only needs to be injected 1-2 times per week for continuously elevated levels of Human Growth Hormone (HGH) and IGF-1. A single subcutaneous (sc) injection results in measurable quantities of CJC-1295 in the blood for up to 13 days. Additionally, a single dose of 60 ug/kg of CJC-1295 results in elevated levels of growth hormone (125%) while the pulsatile secretion of GH is maintained. Furthermore, 60 ug/kg of CJC-1295 elevated IGF-1 levels to the upper limit of normal. A dose of 30 ug/kg of CJC-1295 given weekly maintained its response with no evidence of desensitization.
The advantage of using CJC-1295 instead of actual HGH injections is that injecting HGH shuts down the body's own natural production and therefore when injections are ceased, the body’s ability to produce it's own HGH may be impaired and take some time to recover. Since CJC-1295 only stimulates the body's own HGH production, this risk is not apparent.
Another very positive benefit of CJC-1295/CJC-1293 is its ability to promote slow wave sleep. Slow wave sleep is also known as deep sleep and is the portion of sleep responsible for the highest level of muscle growth and memory retention. SWS are decreased significantly in older adults and also with people who tend to exercise later in the evening. This peptide has a benefit to side effect ratio that exceeds all others currently being legally sold and would make a great addition to ones training regimen or post cycle therapy.
Clinical Research was first conducted for CJC-1295 during the mid-2000s. The objective of the peptide was to treat visceral fat deposits in obese AIDS patients, as increased levels of exogenous hgH are presumed to increase lipolysis (fat loss). The clinical research was ultimately successful for most research subjects.
DAC or no DAC
When a person sees the term CJC 1295 without DAC this is really means that they are looking at MOD GRF 1-29. This tetrasubstitued peptide is a modified version of the original GRF 1-29 peptide better known as Semorelin. Due to the extreme short half life of the original GRF 1-29, chemists were able to modify the peptide to offer a longer biological activity that reduced the metabolic clearance. Although with MOD GRF 1-29 its modification had resulted in a greater peptide bond, the average user will still likely need to inject two to three times a day with a GHRP to get the maximum effectiveness for releasing endogenous growth hormone.
Now when the drug affinity complex (DAC) was added to CJC 1295, it allowed for an even greater possibility to utilize smaller GH pulses (what was once thought of as a bleed) that, when combined with a GHRP, will activate growth hormone stores to release throughout the day and night. When the DAC component was added, this allowed the peptide half-life to be extended to about one week and also provided for steadier blood levels after injection. Now that we understand how important the DAC factor is, this becomes a much more viable and cost effective way to utilize CJC 1295 with DAC along with a GHRP.
The DAC, when added, is able to bind to albumin that circulates the body, literally being able to last for days as it looks for receptors to bind to. So, in short, if you prefer to use shorter spikes of GH release then the use of the MOD GRF 1-29 (CJC 1295 without DAC) is going to be optimal. However, if your prefer fewer injections and still want to unleash your growth hormone stores, then 2-3 times a week injections of CJC 1295 with DAC along with your daily injection of GHRP would be the way to proceed for maximizing growth hormone release.
Dosages and Usage
The naming might have thrown you for a loop, but don’t let that stop you from understanding the reason why you should utilize one of the best GHRH’s out there. CJC 1295 is probably the best and most widely use GHRH along with your chosen GHRP. Like all of the other peptides you are dealing with, it is a delicate lyophilized powder that should be kept out of the light and in a cool dry place. Reconstitution is done with bacteriostatic water or sodium chloride meant for injection.
As already stated before, to mimic the natural release of growth hormone through the natural spikes you would achieve through the day MOD GRF 1-29 (CJC 1295 without DAC) should be injected 1-3 times per day at 100mcg-200mcg doses along with your GHRP of choice. Now, the most cost effective and in my opinion better way to utilize CJC 1295 is to go with the CJC 1295 with DAC. This will allow the bodybuilder or athlete to inject 2mg of CJC 1295 with DAC twice weekly along with their daily injection of GHRP. This will offer smaller but more frequent growth hormone pulses that would ideally get a user closer to exogenous HGH doses.
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